Solution | Technical Application of UHPLC-TQMS G1 for the Detection of 11 Perfluorinated Compounds

The newly revised GB/T 5750 'Testing Methods for Drinking Water Standards' came into effect on April 1, 2023. As a comprehensive upgrade to GB/T 5750-2006, it not only provides critical technical support for the updated GB 5749 'Hygienic Standards for Drinking Water' but also establishes a systematic testing methodology framework for evaluating the hygienic safety of drinking water.

However, for most laboratories, independently establishing and validating testing methods that comply with new standards often faces challenges such as prolonged timelines, high costs, and technical difficulties, particularly in areas like method optimization, issue identification, and result validation. To address this, Aliben provides standardized testing methods and end-to-end application support tailored to the GB/T 5750 series standards, assisting laboratories in rapidly completing method development and validation. This ensures that testing operations not only meet regulatory requirements but also enhance operational efficiency.

This study established linear and detection limit analysis methods for 11 perfluorinated compounds based on the Aliben UHPLC-TQMS G1 platform. The linear correlation coefficients R² for all 11 perfluorinated compounds ranged from 0.5 to 50 ng/mL, with all values exceeding 0.99. The instrument detection limit was determined to be 0.004–0.027 ng/mL.

The linear range of the compounds is shown in the table below, with standard curves for each compound presented in Figure 1. The overlapping mass response curves (MRM) for each compound at 10 ng/mL are displayed in Figure 2. All compounds exhibit good linearity, with R² values exceeding 0.99.

An injection of 5 μL from the 0.5 ng/mL mixed standard solution was used, with the signal-to-noise ratio and detection limits for each compound listed in the table below.

In the future, Aliben will continue to deepen the application of the UHPLC-TQMS G1 series in water quality monitoring and environmental safety fields. Through method innovation and standard adaptation, we will provide sensitive, stable, and efficient solutions for more testing scenarios, driving the water quality monitoring industry toward greater precision, standardization, and intelligence. With technology, we will safeguard the safety of every drop of water.

In the future, Aliben will continue to deepen the application of the UHPLC-TQMS G1 series in water quality monitoring and environmental safety fields. Through method innovation and standard adaptation, we will provide sensitive, stable, and efficient solutions for more testing scenarios, driving the water quality monitoring industry toward greater precision, standardization, and intelligence. With technology, we will safeguard the safety of every drop of water.